We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Read More
8
Beta-glucan shows cognitive improvements
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a randomized, double-blind, placebo-controlled trial to explore how yeast beta-glucan, along with multivitamins, affects individuals suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In our study, 65 participants received either beta-glucan combined with vitamins and zinc or a placebo for 36 weeks.
Interestingly, while our primary focus was on beta-glucan, which was shown to significantly improve cognitive fatigue, the role of vitamin D3 within this combination was not clearly established. This makes it challenging to directly assess the impact of vitamin D3 alone on chronic fatigue syndrome outcomes.
Overall, we discovered that beta-glucan supplementation could positively influence cognitive fatigue, offering promise for future research on nutritional support in ME/CFS patients. However, definitive conclusions about vitamin D3's effectiveness remain inconclusive due to the combined nature of the treatment.
Read More
Most Useful Reviews
9
Improved energy levels
91 people found this helpful
I've been taking this vitamin for 3 months and can see the difference. My quality of life has improved immensely, with no more fatigue or lack of motivation to get out of bed. I feel more energised, can concentrate better, and my mood has significantly improved. I highly recommend it.
Read More
9
Fatigue vanished
28 people found this helpful
Good product! I take it with selenium, zinc, iron, and vitamin C. I noticed the effects within 2 weeks. Chronic fatigue vanished, and I have significantly more energy. If my review was helpful, please give a thumbs up!
Read More
9
Fatigue resolved
19 people found this helpful
It works! After 8 months of constant fatigue, lethargy, and apathy, I couldn't even enjoy a holiday. Following a friend's advice to check my vitamin D, I discovered I had a deficiency. After taking this product for 2 weeks, all my fatigue disappeared, and I can now truly enjoy life again. I highly recommend it!
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a randomized, double-blind, placebo-controlled trial to explore how yeast beta-glucan, along with multivitamins, affects individuals suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In our study, 65 participants received either beta-glucan combined with vitamins and zinc or a placebo for 36 weeks.
Interestingly, while our primary focus was on beta-glucan, which was shown to significantly improve cognitive fatigue, the role of vitamin D3 within this combination was not clearly established. This makes it challenging to directly assess the impact of vitamin D3 alone on chronic fatigue syndrome outcomes.
Overall, we discovered that beta-glucan supplementation could positively influence cognitive fatigue, offering promise for future research on nutritional support in ME/CFS patients. However, definitive conclusions about vitamin D3's effectiveness remain inconclusive due to the combined nature of the treatment.
Read More
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Read More
User Reviews
USERS' SCORE
Good
Based on 22 Reviews
8.5
All Reviews
Positive Reviews
Negative Reviews
9
Improved energy levels
91 people found this helpful
I've been taking this vitamin for 3 months and can see the difference. My quality of life has improved immensely, with no more fatigue or lack of motivation to get out of bed. I feel more energised, can concentrate better, and my mood has significantly improved. I highly recommend it.
Read More
9
Fatigue vanished
28 people found this helpful
Good product! I take it with selenium, zinc, iron, and vitamin C. I noticed the effects within 2 weeks. Chronic fatigue vanished, and I have significantly more energy. If my review was helpful, please give a thumbs up!
Read More
9
Fatigue resolved
19 people found this helpful
It works! After 8 months of constant fatigue, lethargy, and apathy, I couldn't even enjoy a holiday. Following a friend's advice to check my vitamin D, I discovered I had a deficiency. After taking this product for 2 weeks, all my fatigue disappeared, and I can now truly enjoy life again. I highly recommend it!
Read More
9
Energy restored
10 people found this helpful
I have not used salt for seven years, leading to iodine deficiency. With this supplement, the fatigue I experienced upon waking subsided, and I no longer feel sleepy at work. My energy has returned.
Read More
7.5
Symptoms alleviated
6 people found this helpful
I previously suffered from tiredness and fatigue due to low vitamin D levels. After taking it, those symptoms disappeared. I plan to continue using it, although the price is a bit high.
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Vitamin D3 K2 is a supplement that combines two vital nutrients: vitamin D3 (cholecalciferol) and vitamin K2 (menaquinone). Vitamin D3 is crucial for maintaining healthy bones and immune function, as it helps the body absorb calcium, which is essential for bone strength. It can be obtained through sunlight exposure, certain foods, and supplements. On the other hand, vitamin K2 plays a significant role in directing calcium to the bones and teeth while preventing it from depositing in the arteries and soft tissues, thus promoting cardiovascular health and overall well-being.
The synergy between vitamin D3 and K2 is particularly important because they work together to ensure that calcium is utilized effectively in the body. While vitamin D3 boosts calcium absorption, vitamin K2 ensures that this calcium is deposited properly in the bones rather than accumulating in the arteries. This combination is believed to support bone density, cardiovascular health, and overall vitality. Many health professionals recommend considering a D3 and K2 supplement, especially for individuals who may be at risk of deficiency or those who live in areas with limited sunlight exposure. Always consult a healthcare provider before starting any new supplement regimen.
Based on user reviews, the timeline for experiencing results from this supplement can vary. Some users reported feeling noticeable effects as quickly as two weeks after starting the regimen. For instance, one individual mentioned that their chronic fatigue vanished within this time frame, allowing them to regain significant energy levels Read Review. Additionally, another reviewer experienced a complete turnaround after just two weeks of use, stating all fatigue had disappeared Read Review.
However, there are also accounts of longer durations before users felt substantial improvements. One user observed a decrease in fatigue after a month of consistent use Read Review. Others mentioned feeling enhancements over a period of three months, suggesting that while some might find relief faster, others could take longer to realize the benefits Read Review. Overall, while rapid results are possible for some, a longer commitment may be necessary for others to achieve noticeable relief from chronic fatigue symptoms.
The research on supplements for Chronic Fatigue Syndrome (CFS) presents mixed results, particularly regarding vitamin D3. A comprehensive study examining high-dose intermittent vitamin D3 revealed that it did not lead to significant improvements in symptoms associated with CFS, such as fatigue or vascular health [2]. Despite initial hopes, this trial indicated that vitamin D3 supplementation alone may not effectively address the challenges faced by individuals with CFS.
On the other hand, a different study explored the combined effects of yeast beta-glucan and multivitamins on cognitive fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). While the beta-glucan component showed promising results in alleviating cognitive fatigue, the role of vitamin D3 specifically remained unclear since it was part of a greater supplementation strategy [1]. These findings suggest that while beta-glucan might be worth exploring further, vitamin D3 does not have robust evidence supporting its effectiveness for CFS.
Based on user reviews, many individuals have reported significant improvements in their symptoms after using this supplement. A notable number of users experienced a marked reduction in fatigue, allowing them to regain energy and motivation. For instance, one user highlighted that their chronic fatigue vanished within just two weeks, enabling them to feel significantly more energized Read Review. Another reviewer echoed similar sentiments, stating that after suffering from fatigue for eight months, they found relief after only two weeks of taking the supplement Read Review.
In addition to fatigue reduction, users noted improvements in overall well-being, including enhanced mood and concentration. One reviewer shared that after three months, their quality of life improved immensely, allowing them to feel energized, focused, and less apathetic Read Review. However, it’s important to remember that individual results can vary, and while some users found relief quickly, others reported needing longer usage before experiencing noticeable improvements Read Review. Overall, this supplement seems to help many users reclaim their vitality and enhance their daily lives.
Users have reported positive experiences when combining this supplement with other vitamins and minerals to help manage Chronic Fatigue Syndrome. For example, one user noted taking the supplement alongside selenium, zinc, iron, and vitamin C, which led to noticeable effects within just two weeks, including a complete disappearance of chronic fatigue Read Review. Additionally, a user mentioned that they experienced improvements in energy and mood by combining the supplement with Omega, further enhancing their ability to mitigate fatigue Read Review.
Another user highlighted the effectiveness of taking the supplement alongside vitamin K, emphasizing that this combination aids in the proper absorption of vitamin D, contributing to reduced fatigue and better overall energy levels Read Review. The integration of complementary vitamins appears to bolster the outcomes of the main supplement, allowing users to achieve a more substantial reduction in their chronic fatigue symptoms, suggesting that carefully curated synergistic combinations might enhance the supplement's effectiveness in addressing fatigue.
Users have reported various experiences regarding the effectiveness of Vitamin D3 K2 in alleviating symptoms of Chronic Fatigue Syndrome (CFS). Many users experienced significant improvements in energy levels and mood after starting supplementation. For instance, one user noted an energetic transformation after just two weeks of taking the vitamin, stating, "Chronic fatigue vanished, and I have significantly more energy" Read Review. Another user echoed similar sentiments, declaring the end of eight months of fatigue after discovering a Vitamin D deficiency: "All my fatigue disappeared" Read Review.
As for dosage, several reviewers mentioned specific instructions or advice from healthcare professionals. One individual reported taking two pills daily, leading to improvements in Vitamin D levels and reduced daytime lethargy Read Review. Another user appreciated combining Vitamin D with K, as recommended by an endocrinologist, suggesting 5,000 IU as an effective dosage Read Review. While users experienced positive outcomes, some indicated that a longer intake may be needed to sustain benefits, especially in the face of chronic conditions Read Review.
9
Fatigue vanished
28 people found this helpful
Good product! I take it with selenium, zinc, iron, and vitamin C. I noticed the effects within 2 weeks. Chronic fatigue vanished, and I have significantly more energy. If my review was helpful, please give a thumbs up!
9
Fatigue resolved
19 people found this helpful
It works! After 8 months of constant fatigue, lethargy, and apathy, I couldn't even enjoy a holiday. Following a friend's advice to check my vitamin D, I discovered I had a deficiency. After taking this product for 2 weeks, all my fatigue disappeared, and I can now truly enjoy life again. I highly recommend it!
7.5
Positive effects noted
1 people found this helpful
The feeling of constant fatigue has diminished since I started taking these vitamins a month ago. I believe there is a positive trend. Prior to my tests, my vitamin D level was 15. The fatigue seems to be lifting.
9
Improved energy levels
91 people found this helpful
I've been taking this vitamin for 3 months and can see the difference. My quality of life has improved immensely, with no more fatigue or lack of motivation to get out of bed. I feel more energised, can concentrate better, and my mood has significantly improved. I highly recommend it.
9
Depression alleviated
My fatigue and depression have vanished, which is very significant for me. I take these in combination with Omega. It’s a fantastic product.
7.5
Boost in energy
1 people found this helpful
Important!!! Why the addition of vitamin K? An endocrinologist advised taking vitamin D with K. For ages, I sought this dosage of 5,000 with vitamin K and found it with this manufacturer. Overall, I am satisfied with the quality. The small capsules are easy to swallow and have no side effects. I advise taking them in the morning with breakfast. After taking one capsule, I feel well, experience more energy, and notice a reduction in fatigue.
7.5
Less lethargy
The doctor prescribed two pills daily, which the bank provided quickly. After repeated tests over several months, my vitamin D level improved significantly. There was previously fatigue and lethargy during the day, but it is now easier to wake up without feeling heavy. However, the positive effects seemed to diminish, suggesting a longer intake may be needed.
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
8
Beta-glucan shows cognitive improvements
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a randomized, double-blind, placebo-controlled trial to explore how yeast beta-glucan, along with multivitamins, affects individuals suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In our study, 65 participants received either beta-glucan combined with vitamins and zinc or a placebo for 36 weeks.
Interestingly, while our primary focus was on beta-glucan, which was shown to significantly improve cognitive fatigue, the role of vitamin D3 within this combination was not clearly established. This makes it challenging to directly assess the impact of vitamin D3 alone on chronic fatigue syndrome outcomes.
Overall, we discovered that beta-glucan supplementation could positively influence cognitive fatigue, offering promise for future research on nutritional support in ME/CFS patients. However, definitive conclusions about vitamin D3's effectiveness remain inconclusive due to the combined nature of the treatment.
References
Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15214504
Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial. Nutr Metab Cardiovasc Dis. 2015;25:287. 10.1016/j.numecd.2014.10.007